Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-280-9 | CAS number: 80-46-6
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
There are no reliable (Klimisch 1 or 2) long-term toxicity studies with invertebrates available with p-tert-amylphenol.
However, a reliable (Klimisch 2) long-term toxicity study with invertebrates has been conducted for p-tert-butylphenol, a structural analogue.
EA of Japan (1996) provides a NOEC of 0.73 mg/L for Daphnia magna.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.73 mg/L
Additional information
There are no reliable (Klimisch 1 or 2) long-term toxicity studies with invertebrates available with p-tert-amylphenol. However, a reliable long-term study with invertebrates is available for the analogue, p-tert-butylphenol. As provided in the Read Across Report, toxicity data for the analogue substance can be used for toxicity assessment of p-tert-amylphenol.
EA of Japan (1996) has conducted a reliable (Klimisch 2) study according to OECD 211 with the analogue, p-tert-butylphenol. Daphnia magna, less than 24 hours old, were exposed to the test substance for 21 days under semi-static conditions. The 21-day NOEC and LOEC, based on reproduction were 0.73 and 2.3 mg/L, respectively.
There are no reliable (Klimisch 1 or 2) long-term toxicity studies with invertebrates available with p-tert-amylphenol. However, a reliable (Klimisch 2) long-term toxicity study with invertebrates has been conducted for the analogue, p-tert-butylphenol and is included in this dossier. The key study, EA of Japan (1996) provides a NOEC of 0.73 mg/L for Daphnia magna. Consequently this value will be taken as the long-term toxicity in aquatic invertebrate’s endpoint for p-tert-amylphenol.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
