Registration Dossier
Registration Dossier
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EC number: 225-218-5 | CAS number: 4724-48-5
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- No data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Summary report of screening study
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- : Screening study in 2 rabbits
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- no
Test material
- Reference substance name:
- Octylphosphonic acid
- EC Number:
- 225-218-5
- EC Name:
- Octylphosphonic acid
- Cas Number:
- 4724-48-5
- Molecular formula:
- C8H19O3P
- IUPAC Name:
- octylphosphonic acid
- Test material form:
- other: no data
- Details on test material:
- - Name of test material (as cited in study report): n-Octylphosphonic acid (Oktanphosphonsäure)
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Himalayan
- Details on test animals or tissues and environmental conditions:
- No data
Test system
- Vehicle:
- physiological saline
- Controls:
- not required
- Amount / concentration applied:
- 0.1ml undiluted or 10% and 1% in 0.9% saline.
- Duration of treatment / exposure:
- Single application, not washed
- Observation period (in vivo):
- 72 hours
- Number of animals or in vitro replicates:
- 2
- Details on study design:
- No data
Results and discussion
In vivo
- Irritant / corrosive response data:
- Undiluted: The following symptoms were observed: complete turbidity of the cornea with iris not visible, no reaction of the iris to light, swelling and reddening of the mucous membranes so that eyelids were completely closed and swelling extended over half the head, with strong discharge. Similar, though less severe symptoms were observed with 10% and 1% solutions.
- Other effects:
- no data
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Interpretation of results:
- other: Classified as corrosive to eyes as per the CLP Regulation EC No 1272/2008
- Conclusions:
- OPA was concluded to be corrosive for the eye.
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