Registration Dossier
Registration Dossier
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EC number: 308-506-6 | CAS number: 98072-52-7
Carcinogenicity
Administrative data
Description of key information
No information on animal testing of "Matte, precious metal" is available. Since, Matte, precious metal 1 contains cadmium ≥ 0.1 % classified for carcinogenicity Carc. 1B, Matte, precious metal 1 possesses carcinogenicity and requires classification as carcinogenic substance Carc. 1B (H350) in accordance with Regulation (EC) 1272/2008. For information on C&L for "Matte, precious metal 2 - Matte, precious metal 3 please refer to the IUCLID endpoint summary "Carcinogenicity - Matte, precious metal 2 - Matte, precious metal 3".
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
Carcinogenicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
Carcinogenicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Justification for classification or non-classification
Carcinogenicity classification of UVCB substances is based on the presence of a constituent ≥ 0.1 % classified for carcinogenicity Carc. 1A or Carc. 1B and on the presence of a constituent ≥ 1 % classified for carcinogenicity Carc. 2, respectively. Since, Matte, precious metal 1 contains cadmium ≥ 0.1 % classified for carcinogenicity Carc. 1B, Matte, precious metal 1 possesses carcinogenicity and requires classification as carcinogenic substance Carc. 1B (H350) in accordance with Regulation (EC) 1272/2008.
It is noted, that no registrants are using Matte, precious metal with a cadmium/cadmium sulphide content of ≥ 0.1 %. The maximum cadmium content in Matte, precious metal is 0.09% (for detailed information please refer to the ID card attached on IUCLID section 13).
Additional information
Substance specific information for the UVCB substance Matte, precious metal 1 is not available for the endpoint "Carcinogenicity". In order to meet the requirements for Annex VII till Annex X of Regulation (EC) 1907/2006, read across information from any constituents being relevant needs to be included. Due to the high number of constituents and variability in C&L of these constituents it was decided to use the classification information from the individual constituents and to calculate the resulting classification by using the “generic concentration limits of ingredients of the mixture classified as carcinogen that trigger classification of the mixture” and respective rules of Regulation (EC) 1272/2006 section 3.6.3.1 “Classification of mixtures when data are available for all ingredients or only for some ingredients of the mixture” with the MeClas tool.This approach has been presented and discussed with ECHA in several meetings.
In total, tree different grades of "Matte, precious metal" (Matte, precious metal 1 – Matte, precious metal 3) were identified by the consortium that could be grouped according to their calculated C&L resulting from the specific composition profile. Thus, for "Matte, precious metal" two C&L entries (i.e., carcinogenic Carc. 1B and Carc. 2, respectively) for carcinogenicity were calculated. Each group is described in a separate endpoint study record and endpoint summary.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
