Matte, precious metal

Endpoint summary

Description of key information

No information on animal testing of Matte, precious metal 3 on acute toxicity is available. The C&L of Matte, precious metal 3 was determined by using the “acute toxicity range estimate (ATE)” and respective rules of Regulation (EC) 1272/2006 section 3.1.3.6 “Classification of mixtures based on ingredients of the mixture”. Applying these rules, the UVCB substance requires classification as acutely harmful via ingestion and inhalation.
The converted acute toxicity point estimate value for acute toxicity, oral route is 500 mg/kg bw in accordance with EU CLP Guidance Annex I Table 3.1.2. The converted acute toxicity point estimate value for acute toxicity, inhalation route is 1500 mg/m³ in accordance with EU CLP Guidance Annex I Table 3.1.2. These values are designed to be used in the calculation of the ATE for classification on a mixture based on its components and do not represent test results.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion

Endpoint conclusion:

adverse effect observed

Acute toxicity: via inhalation route

Endpoint conclusion

Endpoint conclusion:

adverse effect observed

Acute toxicity: via dermal route

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed

Dose descriptor:

discriminating dose

Value:

2 000 mg/kg bw

Additional information

Substance specific information for the UVCB substance "Matte, precious metal" as such is not available for the endpoint "Acute Toxicity". In order to meet the requirements for Annex VII - Annex X of Regulation (EC) 1907/2006, read across information from any constituent being relevant needs to be included. Due to the high number of constituents and variability in C&L of these constituents it was decided to use the classification information from the individual constituents and to calculate the resulting classification by using the “acute toxicity range estimate (ATE)” and respective rules of Regulation (EC) 1272/2006 section 3.1.3.6 “Classification of mixtures based on ingredients of the mixture” with the aid of the MeClas tool. This approach has been presented and discussed with ECHA in several meetings.

In total, tree different grades of "Matte, precious metal" (Matte, precious metal 1 – Matte, precious metal 3) were identified by the consortium that could be grouped according to their calculated C&L resulting from the specific composition profile. Thus, for "Matte, precious metal" two C&L entries (i.e., no C&L and “harmful if swallowed and inhaled”, respectively) for acute toxicity were calculated. Each group is described in a separate endpoint study record and endpoint summary.

Justification for classification or non-classification

The available information indicates that Matte, precious metal 3 is harmful via ingestion and inhalation, but not acutely toxic or harmful via the dermal route. Matte, precious metal 3 requires classification as harmful if swallowed (Acute Tox. 4) and harmful if inhaled (Acute Tox. 4) according to Regulation (EC) 1272/2008. Classification of Matte, precious metal 3 for acute toxicity via the dermal route is not required according to Regulation (EC) 1272/2008.

Specific target organ toxicant (STOT) - single exposure: oral, inhalation and dermal
The classification criteria according to Regulation (EC) 1272/2008 as specific target organ toxicant (STOT) – single exposure are not met since any adverse health effects, including reversible and irreversible, were not observed immediately or delayed after exposure.