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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Basic toxicokinetics

Currently viewing:

Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
accepted: June 1952
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Abstract

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1952

Materials and methods

Objective of study:
absorption
excretion
Test guideline
Qualifier:
no guideline followed
Guideline:
other: n.a.
Deviations:
not applicable
Principles of method if other than guideline:
Chronical application of Methylparaben to dog for 1 year, determination of urinary excretion.
GLP compliance:
no
Remarks:
performed before GLP guidelines

Test material

Constituent 1
Chemical structure
Reference substance name:
Methyl 4-hydroxybenzoate
EC Number:
202-785-7
EC Name:
Methyl 4-hydroxybenzoate
Cas Number:
99-76-3
Molecular formula:
C8H8O3
IUPAC Name:
methyl 4-hydroxybenzoate
Constituent 2
Reference substance name:
Methyl Parasept
IUPAC Name:
Methyl Parasept
Details on test material:
No details stated
Radiolabelling:
not specified

Test animals

Species:
dog
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on exposure:
No details stated
Duration and frequency of treatment / exposure:
daily for 1 year
Doses / concentrations
Remarks:
Doses / Concentrations:
1 g/kg bw/d
No. of animals per sex per dose / concentration:
1 dog/dose
Control animals:
no
Positive control reference chemical:
None
Details on study design:
No further details
Details on dosing and sampling:
No further details
Statistics:
None

Results and discussion

Preliminary studies:
No data

Toxicokinetic / pharmacokinetic studies

Details on absorption:
Please refer to "overall remarks"
Details on distribution in tissues:
Not determined
Details on excretion:
The rate of urinary excretion in the dog had increased to such an extent that after 24 hours 96% of the dose was recovered in the urine, whereas in a dog given a single oral dose it was not until 48 hours that the entire amount was accounted for.

Metabolite characterisation studies

Metabolites identified:
not specified
Details on metabolites:
No data

Any other information on results incl. tables

None

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): no bioaccumulation potential based on study results
From this study it appears that Methylparaben is efficiently absorbed, metabolised and excreted by the body. Hydrolysis of the ester linkage and metabolic conjugation provide adequate degradation mechanisms. There was no sign of accumulation.
Executive summary:

Please refer to "excretion" and "overall remarks"