Registration Dossier
Registration Dossier
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EC number: 700-129-9 | CAS number: 2004-62-8
Eye irritation
Administrative data
- Endpoint:
- eye irritation
- Remarks:
- other: Rabbit enucleated eye test
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Testing was conducted on 13 Augus 2009
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Fully GLP compliant study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Rabbit Enucleated Eye test
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 3,3'-(hexane-1,6-diyldiimino)dipropanenitrile
- EC Number:
- 700-129-9
- Cas Number:
- 2004-62-8
- Molecular formula:
- C12H22N4
- IUPAC Name:
- 3,3'-(hexane-1,6-diyldiimino)dipropanenitrile
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- The study was designed to assess the ocular ittitancy potential of the test material in the rabbit following application onto the cornea of the enucleated eye.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: Degree of Corneal Opacity
- Basis:
- mean
- Time point:
- other: 60 minutes
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- not specified
- Irritation parameter:
- other: Area of Corneal Opacity
- Basis:
- mean
- Time point:
- other: 60 minutes
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- Following assessment of the data for all endpoints the test material was considered to have the potential to cause severe ocular irritancy in vivo.
- Executive summary:
Following assessment of the data for all endpoints the test material was considered to have the potential to cause severe ocular irritancy in vivo.
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