Tetramethylammonium hydroxide

Partition coefficient

Link to relevant study record(s)

Reference

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Study period:

18 September 2012 - 17 December 2012

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Reason / purpose for cross-reference:

reference to other study

Remarks:

validated analytical method used for quantification of the water and octanol samples

Qualifier:

according to guideline

Guideline:

EU Method A.8 (Partition Coefficient)

Version / remarks:

(2008)

Deviations:

no

Qualifier:

according to guideline

Guideline:

OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)

Version / remarks:

(1995)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7550 (Partition Coefficient, n-octanol / H2O, Shake Flask Method)

Version / remarks:

(1996)

Deviations:

no

GLP compliance:

yes

Type of method:

flask method

Partition coefficient type:

octanol-water

Analytical method:

high-performance liquid chromatography

Key result

Type:

Pow

Partition coefficient:

< 0.036

Temp.:

20 °C

pH:

7

Key result

Type:

log Pow

Partition coefficient:

< -1.4

Temp.:

20 °C

pH:

7

Table: Results Shake flask method

Ratio n-octanol : water [v:v]	Analysed concentration		Pow		log Pow	pH
	n-octanol [g/l]	Water [g/l]	individual	mean
1:1	<0.00498	0.140	<3.5 E-2	<3.5 E-2	< -1.5	7.0
	<0.00495	0.140	<3.5 E-2		< -1.5	7.0
1:2	<0.00497	0.096	<5.2 E-2	<4.9 E-2	< -1.3	7.0
	<0.00498	0.107	<4.6 E-2		< -1.3	7.0
2:1	<0.00488	0.217	<2.2 E-2	<2.5 E-2	< -1.6	7.0
	<0.00497	0.185	<2.7 E-2		< -1.6	7.0

 

The log Pow values were within the criterion range of ± 0.3 log units. Based on this, the Pow and log Pow of the test substance are given as the mean value of all measurements.

 

Conclusions:

The log Pow of the substance at pH 7 and 20°C was determined to be < -1.4 (Pow < 3.6 E-02).

Executive summary:

The log Pow of the substance was determined using the shake-flask method in a GLP study according to EC A.8, OECD 107 and OPPTS 830.7550. The log Pow of the substance at pH 7 and 20°C was determined to be  < -1.4 (Pow  < 3.6 E-02).

Description of key information

log Pow at pH 7 and 20°C: < -1.4 (shake flask method: EC A.8, OECD 107, OPPTS 830.7550).

Pow at pH 7 and 20°C: < 3. 6 E-02.

Key value for chemical safety assessment

Log Kow (Log Pow):

-1.4

at the temperature of:

20 °C

Additional information

Key value for CSA: log Pow < -1.4 at the temperature of 20°C