Registration Dossier
Registration Dossier
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EC number: 201-234-8 | CAS number: 79-92-5
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Analogue approach: The target substance Camphene and the source substance 5-ethylidenebicyclo[2.2.1]hept-2-ene share the same organic functional group (cycloalkene).
Data source
Reference
- Reference Type:
- other: read-across
- Title:
- Unnamed
- Year:
- 2 010
Materials and methods
- Principles of method if other than guideline:
- The reporting form for analogue approach is attached.
- GLP compliance:
- not specified
- Test type:
- other: no data
Test material
- Reference substance name:
- 5-ethylidene-8,9,10-trinorborn-2-ene
- EC Number:
- 240-347-7
- EC Name:
- 5-ethylidene-8,9,10-trinorborn-2-ene
- Cas Number:
- 16219-75-3
- IUPAC Name:
- 5-ethylidenebicyclo[2.2.1]hept-2-ene
- Details on test material:
- - Name of test material (as cited in study report): 5-ethylidenebicyclo[2.2.1]hept-2-ene
- Molecular formula (if other than submission substance): C9H12
- Molecular weight (if other than submission substance): 120.19
- Smiles notation (if other than submission substance): C1(\[C@@H]2C[C@@H](C1)C=C2)=C\C
- InChl (if other than submission substance): InChI=1/C9H12/c1-2-8-5-7-3-4-9(8)6-7/h2-4,7,9H,5-6H2,1H3/b8-2+
- Structural formula attached as image file (if other than submission substance): see attached illustration.
Constituent 1
Test animals
- Species:
- rabbit
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
Any other information on results incl. tables
The analogue 5-ethylidenebicyclo[2.2.1]hept-2-ene which shares the same functional group with Camphene, also has comparable values for the relevant molecular properties. These properties are:
- log Pow value which is 3.67 for 5-ethylidenebicyclo[2.2.1]hept-2-ene and 4.22 for Camphene,
- water solubility which is 15.91 mg/l at 25 ºC for 5-ethylidenebicyclo[2.2.1]hept-2-ene and 4.2 mg/l for Camphene at 20 º C and
- similar molecular weights which are 120.19 for 5-ethylidenebicyclo[2.2.1]hept-2-ene and 136.23 for Camphene.
The reporting form for analogue approach is attached.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The dermal LD50 for the substance 5-ethylidenebicyclo[2.2.1]hept-2-ene is greater than 2000 mg/kg bw. Based on the read-across approach, the dermal LD50 for the substance Camphene is also greater than 2000 mg/kg bw.
- Executive summary:
The analogue 5-ethylidenebicyclo[2.2.1]hept-2-ene which shares the same functional group with Camphene, also has comparable values for the relevant molecular properties. These properties are:
- log Pow value which is 3.67 for 5-ethylidenebicyclo[2.2.1]hept-2-ene and 4.22 for Camphene,
- water solubility which is 15.91 mg/l at 25 ºC for 5-ethylidenebicyclo[2.2.1]hept-2-ene and 4.2 mg/l for Camphene at 20 º C and
- similar molecular weights which are 120.19 for 5-ethylidenebicyclo[2.2.1]hept-2-ene and 136.23 for Camphene.
The dermal LD50 for the substance 5-ethylidenebicyclo[2.2.1]hept-2-ene is greater than 2000 mg/kg bw. Based on the read-across approach, the dermal LD50 for the substance Camphene is also greater than 2000 mg/kg bw.
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