Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Analogue approach: The target substance Camphene and the source substance 5-ethylidenebicyclo[2.2.1]hept-2-ene share the same organic functional group (cycloalkene).

Data source

Reference
Reference Type:
other: read-across
Title:
Unnamed
Year:
2010

Materials and methods

Principles of method if other than guideline:
The reporting form for analogue approach is attached.
GLP compliance:
not specified
Test type:
other: no data

Test material

Constituent 1
Reference substance name:
5-ethylidene-8,9,10-trinorborn-2-ene
EC Number:
240-347-7
EC Name:
5-ethylidene-8,9,10-trinorborn-2-ene
Cas Number:
16219-75-3
IUPAC Name:
5-ethylidenebicyclo[2.2.1]hept-2-ene
Details on test material:
- Name of test material (as cited in study report): 5-ethylidenebicyclo[2.2.1]hept-2-ene
- Molecular formula (if other than submission substance): C9H12
- Molecular weight (if other than submission substance): 120.19
- Smiles notation (if other than submission substance): C1(\[C@@H]2C[C@@H](C1)C=C2)=C\C
- InChl (if other than submission substance): InChI=1/C9H12/c1-2-8-5-7-3-4-9(8)6-7/h2-4,7,9H,5-6H2,1H3/b8-2+
- Structural formula attached as image file (if other than submission substance): see attached illustration.

Test animals

Species:
other: rat and mouse

Administration / exposure

Route of administration:
oral: unspecified

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw

Any other information on results incl. tables

The analogue 5-ethylidenebicyclo[2.2.1]hept-2-ene which shares the same functional group with Camphene, also has comparable values for the relevant molecular properties. These properties are:

- log Pow value which is 3.67 for 5-ethylidenebicyclo[2.2.1]hept-2-ene and 4.22 for Camphene,

- water solubility which is 15.91 mg/l at 25 ºC for 5-ethylidenebicyclo[2.2.1]hept-2-ene and 4.2 mg/l for Camphene at 20 º C and

- similar molecular weights which are 120.19 for 5-ethylidenebicyclo[2.2.1]hept-2-ene and 136.23 for Camphene.

The reporting form for analogue approach is attached.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The oral LD50 for the substance 5-ethylidenebicyclo[2.2.1]hept-2-ene is greater than 2000 mg/kg bw. Based on the read-across approach, the oral LD50 for the substance Camphene is also greater than 2000 mg/kg bw.
Executive summary:

The analogue 5-ethylidenebicyclo[2.2.1]hept-2-ene which shares the same functional group with Camphene, also has comparable values for the relevant molecular properties. These properties are:

- log Pow value which is 3.67 for 5-ethylidenebicyclo[2.2.1]hept-2-ene and 4.22 for Camphene,

- water solubility which is 15.91 mg/l at 25 ºC for 5-ethylidenebicyclo[2.2.1]hept-2-ene and 4.2 mg/l for Camphene at 20 º C and

- similar molecular weights which are 120.19 for 5-ethylidenebicyclo[2.2.1]hept-2-ene and 136.23 for Camphene.

The oral LD50 for the substance 5-ethylidenebicyclo[2.2.1]hept-2-ene is greater than 2000 mg/kg bw. Based on the read-across approach, the oral LD50 for the substance Camphene is also greater than 2000 mg/kg bw.