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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

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Toxicological information


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Administrative data

Description of key information

There are a multitude of published studies, including both animal and epidemiological studies, that address the carcinogenicity of Cr(VI) substances. The literature is summarised in various peer reviewed publications, e. g., EU RAR 2005 and ATSDR, 2012.

Chromium(VI) causes lung tumours in humans and animals by the inhalation route and tumours of the gastrointestinal tract in animals by the oral route. These are both local, site-of-contact tumours – there is no evidence that Cr(VI) causes tumours elsewhere in the bo

Reference dose response relationships for the carcinogenicity of hexavalent chromium substances are documented in the ECHA publication "Application for authorisation: Establishing a reference dose response relationship for carcinogenicity of hexavalent chromium", Ref RAC/27/2013/06 Rev.1, dated 4 Dec 2013.

Key value for chemical safety assessment

Justification for classification or non-classification

Dichromium tris(chromate) is classified as a Carcinogen Category 1B, H350 according to Regulation (EC) No 1272/2008. No studies are available for dichromium tris(chromate), however studies in rats and mice with another Cr (VI) salt (sodium dichromate) demonstrated clear evidence of carcinogenicity via the oral exposure route. Therefore, no change to the current classification is proposed.

Additional information