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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Fluoride salts are not considered irritants to the skin or eyes based on results of rabbit skin and eye irritation testing.  

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

In rabbits (Allied Corp., 1983), no signs of skin corrosion or skin irritation (erythema and/or edema) were observed after a 4 -hour topical (occluded) exposure to potassium bifluoride. The skin was observed and scored for signs of irritation/corrosion immediately after patch removal and again at 48 hours after patch removal.

In a rabbit eye irritation test (Proctor & Gamble, 1971), in which an undiluted liquid test material containing 1% phosphate (as sodium phosphate) and 100 ppm fluoride (as sodium fluoride) was applied to the eyes, very mild irritaiton (slight conjunctivitis) was produced in two of three test eyes 1 hour after dosing. No signs of irritation were visible 24 hours later; the eye irritation was fully reversible.

Effects on eye irritation: slightly irritating

Justification for classification or non-classification