Registration Dossier
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EC number: 202-464-1 | CAS number: 95-92-1
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
EC50 for aquatic invertebrates is 15 mg/L
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 15 mg/L
Additional information
Short-term toxicity of diethyl oxalate to aquatic invertebrates (Daphnia magna) was examined according to OECD test guideline 202 and GLP (BorsodChem 2011). However, the test report lacks information on preparation or stirring time of the stock solution. The obvious fluctuations show that the hydrolysis of Diethyl oxalate already started well before the test organisms were introduced and proceeded during the study period. No information can be obtained from the study to which concentrations of Diethyl oxalate and/or Oxalic acid the daphnids were exposed to during the course of the study. However, as outlined above, it is very likely that Oxalic acid is the relevant compound when Diethyl oxalate comes into contact with water. Though no adverse effects on Daphnia have been observed in the study, it therefore appears reasonable to disregard the study due to its methodological limitations. Instead, using a worst-case approach, the information available for Oxalic acid (and the second hydrolysis product, ethanol), should be used to assess the aquatic hazard of Diethyl oxalate (for more detailed information on the approach taken, please see the read-across justification attached to chapter 13 of this dossier).
The short-term toxicity of Oxalic acid (CAS 144-62-7) to Daphnia magna according to OECD 202 reveals an EC50 (48h) of 15.0 mg/L based on mortality (NITE 1998) and 162.2 mg/L based on mobility (ECHA disseminated dossier, accessed 13 July 2018).
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