(1-methylethylidene)di-4,1-phenylenetetraphenyl diphosphate

Short-term toxicity to fish

Administrative data

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

The data comes from a report of NATIONAL INDUSTRIAL CHEMICALS NOTIFICATION AND ASSESSMENT SCHEME (NICNAS), which is administered by the National Occupational Health and Safety Commission (NOHSC) of Australian Commission. Also the Data were determined by OECD guideline.

Data source

Reference

Reference Type:

review article or handbook

Title:

Phosphoric acid, (1-methylethylidene) di-4,1-phenylene tetraphenyl ester (Fyrolflex BDP)

Author:

National Occupational Health and Safety Commission (Australia)

Year:

2000

Bibliographic source:

In:NATIONAL INDUSTRIAL CHEMICALS NOTIFICATION AND ASSESSMENT SCHEME

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 203 (Fish, Acute Toxicity Test)

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

-

EC Number:

425-220-8

EC Name:

-

Cas Number:

5945-33-5

Molecular formula:

C39H34O8P2

IUPAC Name:

(1-methylethylidene)di-4,1-phenylenetetraphenyl diphosphate

Sampling and analysis

Analytical monitoring:

yes

Details on sampling:

A Static Limit Test (no replacement of test water) was performed over 96 hours using a solution of the test substance made up at a nominal concentrationof 1 mg/L in charcoal filtered dechlorinated tap water. The test was performed in duplicate using ten fish in each test vessel. A solvent control was also run in parallel, also using ten fish.

Test solutions

Vehicle:

yes

Details on test solutions:

The test substance was firstly dissolved in dimethylformamide to produce a 10 g/L solution. An aliquot of this was added to the test vessels in order to produce the indicated nominal concentrations.

Test organisms

Test organisms (species):

Oncorhynchus mykiss (previous name: Salmo gairdneri)

Study design

Test type:

static

Water media type:

freshwater

Limit test:

yes

Total exposure duration:

96 h

Test conditions

Hardness:

around 100 mg/L as CaCO3

Test temperature:

controlled at 14 ± 1 °C

pH:

always between 7.7 and 8.0

Dissolved oxygen:

between 9.4 and 10.1 mg/L

Nominal and measured concentrations:

It is to be noted that the nominal concentration of 1.0 mg/L for the test chemical was greater than the measured water solubility (0.4 mg/L), and in order to attain this nominal concentration, the test substance was firstly dissolved in dimethylformamide to produce a 10 g/L solution. An aliquot of this was added to the test vessels in order to produce the indicated nominal concentrations.However, analysis of samples of the test solutions taken at 0, 24 and 96 hours indicated up to 115% recovery of the test compound. Presumably the presence of the dimethylformamide in the water helped maintain this high solution concentration. It was noted in the report that during work on the initial range finding study test material precipitated out of solution at concentrations in excess of 1.0 mg/ L.

Results and discussion

Effect concentrations

Effect concentrations 1

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

> 1 mg/L

Nominal / measured:

nominal

Effect concentrations 2

Duration:

96 h

Dose descriptor:

NOEC

Effect conc.:

> 1 mg/L

Nominal / measured:

nominal

Any other information on results incl. tables

Sublethal observations / clinical signs:

All test specimens survived over the 96-hour test period. Further, no physical or behavioural anomalies were observed during the test period, and accordingly which it was concluded that the BDP is non toxic to rainbow trout up to the limits of its water solubility.

Applicant's summary and conclusion

Conclusions:

All test specimens survived over the 96-hour test period. It was concluded that the BDP is non toxic to rainbow trout up to the limits of its water solubility.