Registration Dossier
Registration Dossier
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EC number: 222-733-7 | CAS number: 3590-84-9
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The following information is available for the short-termtoxicity to fish endpoint:
- M. H. J. Migchielsen (2004). TRIBUTYLCHLOROSTANNANE [TRIBUTYLTIN CHLORIDE, CAS NO. 1461-22-9]: 96-HOUR ACUTE TOXICITY STUDY IN ZEBRA-FISH (SEMI-STATIC). Testing laboratory: NOTOX B. V., Hambakenwetering 7, 5231 DD 's-Hertogenbosch, The Netherlands. Report no.: 375029. Owner company: Organotin Environmental Programme (ORTEP) Association Stabilizer Task Force. Report date: 2044-12-20.
- Steinhaeuser et al, 1985, Untersuchungen zur aquatischen toxizitat zinnorganischer verbindungen (Investigation on the Aquatic Toxicity of Organotin Compounds), Vom Wasser 65: 203-214.
Migchielson, 2004, is presented as the key information as the reliability rating for this study is 2, according to the criteria of Klimisch, 1997, and so is the most reliable study.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 0.52 mg/L
Additional information
The Migchielson, 2004 study was performed in accordance to the OECD Guideline for testing number 203 and also EC Method C.1. The 96 -hour acute toxicity study in zebra-fish on TTOT was run as a limit test, which was combined with a range-finding test in a semi-static system with daily renewal. Seven zebra-fish per test group were exposed to a blank control and a WAF testing solution prepared at a nominal TTOT loading of 100 mg/l in the limit test, while three zebra-fish were exposed to dilutions containing 0.1, 1.0 and 10% WAF prepared solutions in the additional range-finding test.
The measured TTOT concentrations decreased by approximately 40% relative to the initial measured concentrations during the 24-hour renewal periods. Analyses further showed poor repeatability of test solution preparation. This was not unexpected considering the extremely low solubility of the test substance in the test medium in combination with the difficulties encountered with the separation of the undissolved from the dissolved fraction, which is a common feature when testing WAFs.
The study met the acceptability criteria prescribed by the protocol and the guidelines and was considered valid.
TTOT induced no visible effects in zebra-fish (Brachydanio rerio) at or below a concentration obtained in a Water Accommodated Fraction (WAF) prepared at a loading rate of 100 mg/l. Based on average measured concentrations the NOEC corresponded to 0.52 mg TTOT per litre. Consequently, the 96h-LC50 for zebra-fish exposed to TTOT exceeded an average exposure concentration of 0.52 mg/l.
The Steinhauser, 1985, study is presented as supporting information only. The study presented a LC50 of 0.4 µg/l. No duration was specified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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