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Solubility in organic solvents / fat solubility

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Reference
Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
28 Oct - 08 Nov 2011
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: based on a guideline for water solubility tests
Qualifier:
according to guideline
Guideline:
other: EU Method A.6 (water solubility)
Qualifier:
according to guideline
Guideline:
other: VTA34N00003.01 (internal method)
Principles of method if other than guideline:
The solubility of the test item was determined in n-octanol instead of water.
GLP compliance:
no
Medium:
n-octanol
Solubility:
47.1 g/L
Temp.:
20 °C
Remarks on result:
other: ± 0.26 g/L , RSD 0.55%
Test substance stable:
not determined

Incubation time (h)

Weighed sample (g)

Average concentration (g/L)

24

1,0077

47,20

48

1,0015

46,79

72

1,0165

47,27

Description of key information

in n-octanol: 47.1 g/L at 20°C (based on flask method as described in EU Method A.6)

Key value for chemical safety assessment

Solubility in organic solvents at 20°C:
47.1 g/L

Additional information

The solubility of the substance Octadecan-1-ol, ethoxylated, < 2.5 EO (CAS 9005-00-9) in n-octanol was determined using the flask method test set-up as described in EU Method A.6.