Registration Dossier
Registration Dossier
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EC number: 203-268-9 | CAS number: 105-08-8
Bioaccumulation: aquatic / sediment
Administrative data
- Endpoint:
- bioaccumulation in aquatic species, other
- Remarks:
- QSAR
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Study period:
- 2009
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data were obtained using QSAR - EPIWIN BCFBAF acceptable in accordance with REACH
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- publication
- Title:
- QSAR Bioaccumulation
- Author:
- anon.
- Year:
- 2 009
- Bibliographic source:
- QSAR EPIWIN BCFBFA
Materials and methods
Test guideline
- Guideline:
- other: QSAR EPIWIN BCFBAF in accordance with REACH
- Principles of method if other than guideline:
- Epiwin bioacumulation model
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Cyclohex-1,4-ylenedimethanol
- EC Number:
- 203-268-9
- EC Name:
- Cyclohex-1,4-ylenedimethanol
- Cas Number:
- 105-08-8
- Molecular formula:
- C8H16O2
- IUPAC Name:
- cyclohexane-1,4-diyldimethanol
Constituent 1
- Radiolabelling:
- no
Study design
- Test type:
- other: computer estimation program
Test conditions
- Details on estimation of bioconcentration:
- BASIS FOR CALCULATION OF BCF
- Estimation software: EPIWIN BCFBAF Program (v3.00)
- Result based on calculated log Pow of: 1.49
Results and discussion
Bioaccumulation factor
- Type:
- BCF
- Value:
- 4.45
- Basis:
- other: L/kg weight weight
- Remarks on result:
- other: estimated Log BCF = 0.65
- Details on results:
- Summary Results:
Log BCF (regression-based estimate): 0.65 (BCF = 4.45 L/kg wet-wt)
Biotransformation Half-Life (days) : 0.0769 (normalized to 10 g fish)
Log BAF (Arnot-Gobas upper trophic): 0.51 (BAF = 3.2 L/kg wet-wt)
Log Kow (experimental): not available from database
Log Kow used by BCF estimates: 1.49
Equation Used to Make BCF estimate:
Log BCF = 0.6598 log Kow - 0.333 + Correction
Correction(s): Value
No Applicable Correction Factors
Applicant's summary and conclusion
- Executive summary:
The bioconcentration factor (BCF) was estimated using the BCFBAF program (v3.00) contained within the U.S. EPA EPI Suite. The BCF was estimated to be 4.45 L/kg weight weight (log BCF = 0.65) based upon the relationship to an estimated log Kow of 1.49.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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