Registration Dossier
Registration Dossier
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EC number: 211-659-0 | CAS number: 682-01-9
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
Toxicity to microorganisms: 3hr EC50 >100 mg/l (activated sludge respiration inhibition, OECD 209), read-across from an analogous substance.
Key value for chemical safety assessment
Additional information
There are no reliable microorganism toxicity data available for tetrapropyl orthosilicate, therefore good quality data for the analogous substance, tetraethyl orthosilicate (CAS 78 -10 -4), have been read across. Both substances share the same hydrolysis product, silicic acid
; the other hydrolysis products being propanol and ethanol, respectively. Propanol and ethanol do not have adverse effects on microorganisms.Both tetrapropyl orthosilicate and tetraethyl orthosilicate are within an analogue group of substances that exhibit no evidence of significant toxicity to microorganisms
It is therefore considered valid to read-across the results for tetraethyl orthosilicate to fill the data gap for the registered substance.Additional information is given in a supporting report (PFA, 2013j) attached in Section 13 of the IUCLID 5 dossier.
A 3hr EC50value of >100 mg/l (nominal) was determined for tetraethyl orthosilicate.
The study is considered to be reliability 1 (reliable without restrictions); the read across of the result is considered to be reliability 2 (reliable with restrictions).Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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