Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

biotransformation and kinetics
Type of information:
experimental study
Adequacy of study:
supporting study
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: well documented publication

Data source

Reference Type:
Molecular Analysis of a Novel Methanesulfonic Acid Monooxygenase from the Methylotroph Methylosulfonomonas methylovora
De Marco P, Moradas-Ferreira P, Higgins TP, McDonald I, Kenna EM, Murrell JC
Bibliographic source:
Journal of Bacteriology 181, 7: 2244-2251

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
Methanesulphonic acid
EC Number:
EC Name:
Methanesulphonic acid
Cas Number:
Molecular formula:
methanesulfonic acid

Results and discussion

Any other information on results incl. tables

Methanesulphonic acid is the simplest of the sulfonates and is a substrate for the growth of certain methylotrophic microorganisms. Such as the facultative methylotroph bacterium Methylosulfonomonas methylovora, which was isolated from garden soil, or the bacterium Marinosulfonomonas methylotropha, which was isolated from the marine environment.

In a first step methanesulphonic acid gets oxidized to formaldehyde, which can then be either assimilated through the serin cycle or fully oxidized to yield CO2 and H2O in order to produce reduction power and energy for the cell. It was shown that the inducible enzyme responsible for the oxidation of methanesulphonic acid is a multicomponent monooxygenase. The multicomponent monooxygenase appears from its substrate specificity to be a unique oxygenase with a rather narrow substrate range. O2 consumption studies and cell extract assays demonstrated a restricted substrate range that includes only short-chain aliphatic sulfonates (methane- to butanesulfonate) and excludes all larger molecules.

Applicant's summary and conclusion