Registration Dossier
Registration Dossier
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EC number: 203-377-1 | CAS number: 106-24-1
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable publication
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Metabolism of Geraniol and Linalool in the Rat and effects on liver and Lung Microsomal Enzymes.
- Author:
- Chadha A, Madyastha M
- Year:
- 1 984
- Bibliographic source:
- Xenobiotica 14: 365-374
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- Chadha A, Madyastha M
- Year:
- 2 008
- Bibliographic source:
- RIFM database
Materials and methods
- Objective of study:
- metabolism
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Geraniol
- EC Number:
- 203-377-1
- EC Name:
- Geraniol
- Cas Number:
- 106-24-1
- Molecular formula:
- C10H18O
- IUPAC Name:
- 3,7-dimethylocta-2,6-dien-1-ol
- Details on test material:
- - Name of test material (as cited in study report): Geraniol
- Analytical purity: >99.5% pure,
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- other: IISc strain
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 160 - 200 g
- Housing: after dosing individually
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on exposure:
- VEHICLE
- Concentration: 1% - Duration and frequency of treatment / exposure:
- 20 days
Doses / concentrations
- Remarks:
- Doses / Concentrations:
800 mg/kg bw/d
Results and discussion
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- geranic acid, 3-hydroxy-citronellic acid, 8-hydroxy-geraniol, 8-carboxy-geraniol
and dicarboxylic acid.
Applicant's summary and conclusion
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