Registration Dossier
Registration Dossier
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EC number: 203-377-1 | CAS number: 106-24-1
Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Remarks:
- comparative study in rat and human hepatocytes to investigate the human relevance of the changes in rat thyroid hormone metabolism by UGT induction
- Type of information:
- other: Study planned
Data source
Materials and methods
- Principles of method if other than guideline:
- Primary cultures of cryopreserved hepatocytes from Wistar rat and three human donors will be cultured and incubated with the test item at different non-cytotoxic concentrations for different time points. A preliminary cytotoxicity study will determine the test item concentrations to be used in the main study. Positive controls samples will be added to the test design.
After treatment periods, the mRNA expression of Cyp2b1 and Cyp3a1 (rat) or CYP2B6 and CYP3A4 (human) and of UGT1A1, UGT1A5/6 (human and rat), UGT1A3, UGT1A9 (human), Ugt2B1 (rat) or UGT2B7 (human) will be measured to determine potential alterations at the transcriptional level. - GLP compliance:
- no
- Type of method:
- in vitro
Test material
- Reference substance name:
- Geraniol
- EC Number:
- 203-377-1
- EC Name:
- Geraniol
- Cas Number:
- 106-24-1
- Molecular formula:
- C10H18O
- IUPAC Name:
- 3,7-dimethylocta-2,6-dien-1-ol
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- other: Primary cultures of cryopreserved hepatocytes from Wistar rat and human donors
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
