Disodium octaborate

Particle size distribution (Granulometry)

Link to relevant study record(s)

Reference

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

15 JUN 2010 to 16 JUN 2010

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Qualifier:

according to guideline

Guideline:

ISO 13320 (Particle size analysis - Laser diffraction methods)

Deviations:

not specified

Qualifier:

according to guideline

Guideline:

other: CIPAC MT 187

Deviations:

not specified

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions) - Method B: Fibre Length and Diameter Distributions

Deviations:

not specified

GLP compliance:

yes

Type of method:

other: Optical microscope analysis and Laser diffraction particle size analysis

Type of distribution:

volumetric distribution

Percentile:

D50

Mean:

12.729 µm

St. dev.:

0.59

Full test results: All results are in μm.

	Run 1	Run 2	Run 3	Run 4	Run 5	* Average
Volume weighted mean	19.301	20.109	19.865	19.231	19.183	19.538
Median (d.50)	12.651	12.839	12.802	12.675	12.686	12.729
Mode (μm)	13.299	13.012	13.108	13.214	13.299	13.189
10 % of material is <	2.781	2.782	2.786	2.787	2.802	2.788
50 % of material is <	12.651	12.839	21.802	12.675	12.686	12.729
90 % of material is <	45.622	47.888	47.008	45.151	45.009	46.122

* Average value was calculated from the entirety of data captured in each run and is not a simple arithmetic mean.

41.27 % by volume of the sample was seen to be < 10.00 μm.

Standard deviation results:

	Run 1	Run 2	Run 3	Run 4	Run 5	Stdev	%STDV
d10	2.781	2.782	2.786	2.787	2.802	0.01	0.27
d50	12.351	12.839	12.802	12.675	12.686	0.08	0.59
d90	45.622	47.888	47.008	45.151	45.009	1.13	2.44
d15.78	58.110	57.380	57.540	58.070	58.060	0.31	0.53
GSD	0.218	0.224	0.222	0.218	0.218	0.00	1.13

Coefficient of variation for d50 was less than 3 %; d10 and d90 were less than 5 %. Thus repeatability of the characteristic particles in the size distribution were within the acceptable limits as per the BS ISO 13320 -1 test standard.

Conclusions:

In particle size distribution analysis 41.27 % by volume of the sample was seen to be < 10.00 μm. Coefficient of variation for d50 was less than 3 %; d10 and d90 were less than 5 %. Thus repeatability of the characteristic particles in the size distribution were within the acceptable limits as per the BS ISO 13320 -1 test standard.

Executive summary:

The particle size distribution of the test item was assessed in a guideline study (OECD 111, ISO 13320, CIPAC MT 187) according to GLP by laser diffraction method. The test item has a d50 of 12.729 µm, a d90 of 46.122 µm and a d10 of 2.788 µm.

Description of key information

The particle size distribution of the test item was assessed in a guideline study (OECD 111, ISO 13320, CIPAC MT 187) according to GLP by laser diffraction method. The test item has a d50 of 12.729 µm, a d90 of 46.122 µm and a d10 of 2.788 µm.