Registration Dossier
Registration Dossier
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EC number: 273-521-6 | CAS number: 68988-22-7 A complex residuum from the distillation of products from the manufacture of dimethyl terephthalate by air oxidation and esterification of p-xylene. It consists of polyphenyl polyesters.
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Information retrieved from secondary source (OECD SIDS report)
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Dimethyl terephthalate, CAS N°: 120-61-6 -SIDS Initial Assessment Report For SIAM 11 - United States, January 23-26, 2001
- Author:
- United States/IT National SIDS Contact Point in Sponsor Country: Oscar Hernandez Director, Risk Assessment Division Office of Pollution Prevention and Toxics US EPA Washington, DC 20460
- Year:
- 2 001
- Bibliographic source:
- OECD - UNEP Chemicals 11-13 chemin des Anémones, CH-1219 Châtelaine Geneva, Switzerland
Materials and methods
- Objective of study:
- absorption
- excretion
- metabolism
- Principles of method if other than guideline:
- combined toxicokinetic information from several in vivo toxicokinetic studies
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Dimethyl terephthalate
- EC Number:
- 204-411-8
- EC Name:
- Dimethyl terephthalate
- Cas Number:
- 120-61-6
- Molecular formula:
- C10H10O4
- IUPAC Name:
- dimethyl terephthalate
- Details on test material:
- Dimetthyl terephthalate
Constituent 1
Administration / exposure
- Route of administration:
- oral: unspecified
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Several studies conducted in rats, rabbits, and mice are summarised in the OECD SIDS document. These studies show that dimethyl terephthalate is readily absorbed from the gastrointestinal tract.
- Details on excretion:
- In the studies summarised in the OECD SIDS document the test substance was rapidly eliminated in the urine within 48-hours
Metabolite characterisation studies
- Details on metabolites:
- Absorbed dimethyl terephthalate was metabolized to terephthalic acid (TPA) via hydrolysis (partly precipitated as TPA-Ca++). In mice, monomethyl terephthalate was the major metabolite.
Applicant's summary and conclusion
- Executive summary:
Information from a peer-reviewed secondary source (OECD SIDS) shows that the major component of the submission substance, dimethyl terephthalate is well absorbed from the gastrointestinal tract, metabolised by hydrolysis to terephthalic acid (in mice: monomethyl terephthalate), and mainly excreted in the urine.
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