1,1'-iminodipropan-2-ol

Acute Toxicity: other routes

Administrative data

Endpoint:

acute toxicity: other routes

Type of information:

experimental study

Adequacy of study:

other information

Study period:

06. Jan 1965 - 19. Jan 1965

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1965

Report date:

1965

Materials and methods

Principles of method if other than guideline:

other: BASF-Test

GLP compliance:

no

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Diisopropanolamine

IUPAC Name:

Diisopropanolamine

Details on test material:

- Name of test material (as cited in study report): Diisopropanolamin

Test animals

Species:

mouse

Strain:

other: Tuebinger-Mice

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: male: 36 g (mean), female: 28 g (mean)

Administration / exposure

Route of administration:

intraperitoneal

Vehicle:

not specified

Doses:

200, 250, 320, 400, 800, 1600 mg/kg

No. of animals per sex per dose:

5

Control animals:

not specified

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

ca. 350 mg/kg bw

Mortality:

1600 mg/kg: all animals died within the first 24 h.
800 mg/kg: all animals died within the first 24 h.
400 mg/kg (8%): 3 males died n the first day, 1 on the second and 1 on the fourth day. 1 female died on the first day, 2 on the second and 1 each on days 5 and 6.
400 mg/kg (4%): 1 male died on day 2 and 1 on day 7. 1 female died within 24 h and one on day 6.
320 mg/kg (4%): 1 male each died on day 3 and 4.
320 mg/kg (2%): 1 male died on day 2.
250 mg/kg (4%): 1 male died on day 6.
250 mg/kg (2%): 1 male died on day 4.

Clinical signs:

1600 mg/kg: Immediatelyy post application high stepping gait, staggering, in intervals clonic convulsions.

800 mg/kg: high stepping gait, intermittent respiration.

400 mg/kg (8%): high stepping gait, intermittent respiration. 4 days after application: very calm attitude, gaunted sides, irregular respiration, agglutinated eyes, aquatting posture, bad general condition.

400 and 320 mg/kg (4%): immediately post application convulsions, intermittent respiration, animals are agressive. One day after application: intermittent respiration, fluffy fur, partly abdominal position. 2 days after application: calm attitude, fluffy fur, accelerated respiration.

320 and 250 mg/kg (2%): 10 min post application abdominal position, flattened ears, accelerated repiration, waddling gait. One day after application: ruffled and partly fluffy fur, accelerated respiration. 2 daysafter application: squatting posture

Gross pathology:

1600 mg/kg: peritoneal and gastrointestinal irritation. Liquid in abdomial cavity.
800 and 400 mg/kg (8%): Liquid in abdominal cavity, gastointestinal irritation, clouded adiposal tissue.
400 mg/kg (4%): Residual substance and agglutination.
250 mg/kg: clouded adiposal tissue.

Any other information on results incl. tables

Mortality:

Dose (mg/kg)	Conc. (%)	1 h	24 h	48 h	7 days	14 days
1600	16	0/10	10/10	10/10	10/10	10/10
800	8	0/10	10/10	10/10	10/10	10/10
400	8	0/10	4/10	7/10	10/10	10/10
400	4	0/10	1/10	2/10	4/10	4/10
320	4	0/10	0/10	0/10	2/10	2/10
320	2	0/10	0/10	1/10	1/10	1/10
250	4	0/10	0/10	0/10	1/10	1/10
250	2	0/10	0/10	1/10	1/10	1/10
200	2	0/10	0/10	0/10	0/10	0/10