Registration Dossier
Registration Dossier
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EC number: 219-460-0 | CAS number: 2439-35-2
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline Study with acceptable restrictions (non-GLP, unknown purity of TS).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- Semiocclusive and occlusive exposure of TS to rabbit skin for 3 min, 1 h and 4 h.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-(dimethylamino)ethyl acrylate
- EC Number:
- 219-460-0
- EC Name:
- 2-(dimethylamino)ethyl acrylate
- Cas Number:
- 2439-35-2
- Molecular formula:
- C7H13NO2
- IUPAC Name:
- 2-(dimethylamino)ethyl prop-2-enoate
- Details on test material:
- - Name of test material (as cited in study report): Dimethylaminoethyl acrylate
- Purity: no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Gaukler, Offenbach, FRG
- Weight at study initiation: mean males: 2.47 kg (3 min) and 3.06 kg (1 and 4 h); mean females: 2.57 kg (3 min) and 3.08 kg (1 and 4 h)
- Housing: single housing in wire mesh cages
- Diet: Solikanin 4 mm (MUSKATOR-WERKE, Düsseldorf, FRG), approx. 130 g per animal per day
- Water: approx. 250 ml per animal per day
- Acclimation period: approx. 8 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 26
- Humidity (%): 30 - 70
- Photoperiod (hrs dark / hrs light): 12 / 12
Test system
- Type of coverage:
- other: semiocclusive and occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 0.5 ml
- Duration of treatment / exposure:
- 3 minutes, 1 hour and 4 hours
- Observation period:
- 7 days
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: 3 x 3 cm (dorsal/flank skin)
REMOVAL OF TEST SUBSTANCE
- Washing: Lutrol and Lutrol/water (1:1)
- Time after start of exposure: 3 min, 1 h, 4 h
SCORING SYSTEM: According to Draize
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 h
- Score:
- 3.4
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: 4 h semiocclusive exposure
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 h
- Score:
- 3.4
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: 4 h semiocclusive exposure
Any other information on results incl. tables
Irritation/corrosion readings after 4 h semiocclusive exposure:
Reading Erythema/Edema in animal No. |
1 |
2 |
3 |
4 |
5 |
6 |
24 h |
3/4 |
3/4 |
4/4 |
3/4 |
3/4 |
3/4 |
48 h |
3/3 |
3/3 |
4/4 |
3/3 |
4/3 |
3/3 |
72 h |
4/3 |
4/3 |
4/3 |
3/3 |
4/3 |
4/3 |
mean |
3.3/3.3 |
3.3/3.3 |
4/3.7 |
3/3.3 |
3.7/3.3 |
3.3/3.3 |
3 minutes semiocclusive exposure lead to irritation, after 1 hour semiocclusive expoure necrosis were observed.
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information
- Conclusions:
- Classification: corrosive (causes burns)
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