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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Meets generally accepted scientific standards, well documented and acceptable for assessment.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1979
Report date:
1979

Materials and methods

Principles of method if other than guideline:
BASF Test: The substance was injected into the peritoneal cavity of mice. One group of 5 mice per sex was treated with a preparation of the test substance in 0.5% CMC at a dose of 200 mg/kg bodyweight. The volume per kg body weight was 10 ml. Documentation of clinical signs was performed over the 14-day study period.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-(dimethylamino)ethyl acrylate
EC Number:
219-460-0
EC Name:
2-(dimethylamino)ethyl acrylate
Cas Number:
2439-35-2
Molecular formula:
C7H13NO2
IUPAC Name:
2-(dimethylamino)ethyl prop-2-enoate
Details on test material:
- Name of test material (as cited in study report): Dimethylaminoethylacrylat
- Purity: > 90 %

Test animals

Species:
mouse
Strain:
NMRI
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Wiga, Sulzfeld, FRG
- Weight at study initiation: mean males: 28 g; mean females: 22 g
- Fasting period before study: 15 - 20 hours before application
- Diet: Herilan MRH-Haltung (H. Eggersmann KG)

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
CMC (carboxymethyl cellulose)
Details on exposure:
ADMINISTRATION VOLUME: 10 ml/kg bw
Doses:
200 mg/kg bw
No. of animals per sex per dose:
5
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
ca. 200 mg/kg bw
Mortality:
Males: 2/5; females: 3/5
Clinical signs:
Dyspnoea, apathy, staggering, scrubby fur, clotted eyes, bad general state.
Gross pathology:
Animals that died and sacrificed animals: No intraabdominal precipitation or agglutination of the test substance.

Any other information on results incl. tables

Mortality data:

 

No. dead / No. dosed

Time after administration

Males

Females

Total

1 h

0/5

0/5

0/10

1 d

0/5

0/5

0/10

2 d

1/5

1/5

2/10

7 d

2/5

3/5

5/10

14 d

2/5

3/5

5/10

 

Mean body weight data:

Time

Males

Females

Start of study

28

22

2-4 d

25.0

18.4

7 d

29.4

20.0

13 d

34.0

23.0

Applicant's summary and conclusion