Registration Dossier
Registration Dossier
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EC number: 219-460-0 | CAS number: 2439-35-2
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
For 2-dimethylaminoethyl acrylate, one GLP OECD guideline (204) study on long-term toxicity to fish is reported. After 14 days of exposure a LC50 of 5.66 mg/L was measured. However, according to Annex IX long-term toxicty tests on fish shall provide information about one of the following parameters: a) early-life stage toxicity; b) short-term toxicity on embryo and sac-fry stages or c) juvenile growth inhibition. Thus, the present prolonged study cannot be taken into account for a long-term toxicity assessment; therefore, the result of this study can just be used for a pre-evaluation of the long-term toxicity of the test substance.
Acute effects levels were in the same concentration range for fish and invertebrates, i.e. between 1 and 10 mg/L. In order to assess long-term toxicity towards aquatic organisms, a 21-day chronic life-cycle study with Daphnia magna was conducted under flow-through conditions. The respective NOEC value for reproduction was 3.0 mg/L.
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