Registration Dossier
Registration Dossier
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EC number: 219-460-0 | CAS number: 2439-35-2
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 0.005 mg/L
- Assessment factor:
- 50
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 0.009 mg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 0.001 mg/L
- Assessment factor:
- 500
- Extrapolation method:
- assessment factor
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 210 mg/L
- Assessment factor:
- 1
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 3.31 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 0.331 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for air
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 0.657 mg/kg soil dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for predators
Additional information
Concerning its environmental fate, 2-(Dimethylamino)ethyl acrylate (ADAME) needs to be considered as charged and uncharged, i.e. dissociated and undissociated molecule. According to a KocWin v2.00 calculation a relevant adsorption of the undissociated ADAME to solid soil phase is not expected (log Koc = 1.1). But under environmental pH values, the substance is expected to be present in the dissociated form. The log Koc was calculated for the charged molecule according to the calculation presented by Franco & Trapp (2008) to be between 3.15 and 3.82 (corresponding Koc = 1404 - 6584) depending on the assumed pH (5.0 - 7.0). Thus, under environmental conditions adsorption to the solid soil phase is to be expected. Therefore, PNEC values for sediment and soil were calculated by means of the equilibrium partitioning method for both, charged and uncharged molecule. Accordingly, the exposure assessment was performed for the uncharged and charged molecule with the corresponding PNECs and Koc values, respectively. The resulting risk characterisation ratios (RCRs) were remarkably similar, e.g. 0.199 for freshwater in the exposure scenario “manufacture” for the dissociated molecule and 0.202 for freshwater in the exposure scenario “manufacture” for the undissociated molecule. Since under environmental conditions the dissociated molecule is expected to prevail, only the PNECs, PECs and RCRs for the dissociated ADAME are reported in the present REACh registration dossier.
Conclusion on classification
- Classification according to Annex VI of Directive 67/548/EEC:
- N, R50
GHS classification (REGULATION (EC) No 1272/2008 (CLP)):
- very toxic to aquatic life (acute category 1)
- harmful to aquatic life with long lasting effects (chronic category 3)
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