Registration Dossier
Registration Dossier
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EC number: 202-259-7 | CAS number: 93-58-3
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data obtained in an official monitoring study presented by German authorities
Data source
Reference
- Reference Type:
- publication
- Title:
- The German Environmental Survey 1990/92 (GerES II): Sources of personal exposure to volatile organic compounds
- Author:
- Hoffmann K, Krause C, Seifert B, Ullrich D
- Year:
- 2 000
- Bibliographic source:
- Journal of Exposure Analysis and Environmental Epidemiology 10, 115-125
Materials and methods
- Type of study / information:
- Personal inhalation exposure to organic volatile compounds at home
- Endpoint addressed:
- other: Inhalation exposure
- Principles of method if other than guideline:
- Exposure of the general public to volatile organic compounds was determined by using personal samplers and sampling over a period of one week.
- GLP compliance:
- no
Test material
- Reference substance name:
- Methyl benzoate
- EC Number:
- 202-259-7
- EC Name:
- Methyl benzoate
- Cas Number:
- 93-58-3
- Molecular formula:
- C8H8O2
- IUPAC Name:
- methyl benzoate
Constituent 1
Method
- Ethical approval:
- other: not required
- Details on study design:
- A random sample of 113 was drawn from the participants of the German Environmental Survey 1990/92. The selected subjects were instructed on how to use the sampler and then wore the sampler over a period of seven days. Sampling was conducted close to the breathing zone of the subjects. At the end of the sampling period, the sampler's collector surface was covered with the lid provided by the manufacturer for this purpose, the sampler was wrapped in aluminium foil and sent to the laboratory for analysis. Subjects were asked to fill in a specific questionnaire. The diffusive samplers were analysed by a gas chromatographic procedure according to the German VDI guideline.
- Exposure assessment:
- measured
Results and discussion
- Results:
- The concentration of methyl benzoate was above the limit of quantification in 35 of 113 samples (31%). The geometric mean of inhalation exposure was 1.8 µg/m3 (confidence interval of 1.6 to 2.1 µg/m3). The 95 percentile of inhalation exposure was 7 µg/m3.
Applicant's summary and conclusion
- Conclusions:
- Methyl benzoate was found in the air of 31% of homes. Subjects were exposed to a geometric mean of 1.8 µg/m3.
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