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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information


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Administrative data

Description of key information

Key value for chemical safety assessment

Effect on immunotoxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed

Additional information

Justification for selection of effect on immunotoxicity via oral route endpoint:
Under experimental conditions of oral administration of dapsone in C57BL/6 mice, Dapsone did not result in a significant degree of immunotoxicity in C57BL/6 mice with the exception of the highest dose. The pattern of immunotoxicity that was observed appeared to be related to a marginal sensitivity in humoral immunity and manifested as augmented responses. In this regard, the possibility of a "rebound" effect cannot be ruled out.

Justification for classification or non-classification