Hexyl acetate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Published screening study for acute oral toxicity; limited methodological detail but sufficient for the purposes of classification

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Unnamed

Year:

1974

Report date:

1973

Reference 2

Reference Type:

secondary source

Title:

Unnamed

Year:

1974

Report date:

2011

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Screening study for acute oral toxicity, with LD50 calculation

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

n-hexyl acetate

IUPAC Name:

n-hexyl acetate

Constituent 2

Reference substance name:

acetic acid hexyl ester

IUPAC Name:

acetic acid hexyl ester

Constituent 3

Reference substance name:

Hexyl acetate

EC Number:

205-572-7

EC Name:

Hexyl acetate

Cas Number:

142-92-7

Molecular formula:

C8H16O2

IUPAC Name:

hexyl acetate

Test material form:

not specified

Details on test material:

No details provided

Test animals

Species:

rat

Strain:

other: Carworth-Wistar

Sex:

male

Details on test animals or test system and environmental conditions:

Groups of 5 non-fasted Carworth-Wistar male rats, 4 - 5 weeks old and weighing 90 - 120 grams, were administered a single dose of the undiluted test material by gastric intubation. The animals were observed for mortality during a 14-day observation period, and the LD50 was estimated by the Thompson and Weil method.

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Details on oral exposure:

Animals were administered a single dose of the undiluted test material by gastric intubation. If lesser concentrations were necessary, the test material was diluted as a solution in water or corn oil, or as a suspension in semi-solid agar.

Doses:

No details provided.

No. of animals per sex per dose:

Groups of five male rats

Control animals:

not specified

Details on study design:

No details

Statistics:

LD50 estimated using Thompson and Weil method

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

LD50

Effect level:

41.5 mL/kg bw

Based on:

test mat.

95% CL:

> 30.7 - < 56.1

Remarks on result:

other: Assuming a specific gravity value of approximately 1 g/mL, the LD50 value is ~41.5 g/kg bw.

Mortality:

No information on rat mortality

Clinical signs:

other: No information provided for clinical signs

Gross pathology:

No information provided in publication

Other findings:

Not reported

Any other information on results incl. tables

The acute oral LD50 was found to be 41.5 g/kg bw.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

Assuming density of 1 g/mL; the acute oral LD50 value of 41.5 mL/kg bw is equivalent to 41500 mg/kg bw or 41.5 g/kg bw.

Executive summary:

Groups of 5 non-fasted Carworth-Wistar male rats, 4 - 5 weeks old and weighing 90 - 120 grams, were administered a single dose of the undiluted test material by gastric intubation. The animals were observed for mortality during a 14-day observation period, and the LD50 was estimated by the Thompson and Weil method. The acute oral median lethal dose is quoted as 41.5 ml/kg bw for rats (confidence limits 30.7 to 56.1 ml/kg bw), equivalent to approximately 41.5 g/kg bw.