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EC number: 201-201-8 | CAS number: 79-38-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian cell study: DNA damage and/or repair
- Remarks:
- Type of genotoxicity: DNA damage and/or repair
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study without detailed documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: the standard operating procedure SOP "GEN-018"-I n -v i v o Assay f o r S i s t e r Chromatid Exchange Induction i n Lymphocytes of Rabbit, June, 1980.
- Deviations:
- no
- GLP compliance:
- no
- Type of assay:
- sister chromatid exchange assay
Test material
- Reference substance name:
- Chlorotrifluoroethylene
- EC Number:
- 201-201-8
- EC Name:
- Chlorotrifluoroethylene
- Cas Number:
- 79-38-9
- Molecular formula:
- C2ClF3
- IUPAC Name:
- 1-chloro-1,2,2-trifluoroethene
- Details on test material:
- Name of the substance as cited in the report: CTFE (Chloro trifluoroethylene)
Storage Conditions Room Temperature
Espiration Date February, 1983
Analysis Purity - 99%
Stability: stable @ room temperature
Constituent 1
Test animals
- Species:
- other: rabbits and rats
- Strain:
- other: strain of the rabbits: New Zealand White; strain of rats: Fisher 344
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- 1.Species: Rat
Strain: Fischer 344
Supplier: Charles River Breeding Laboratories Kingston, N.Y.
Reason for Species Choice: Standard Laboratory Test Systems
Age on Test: Not defined
Weight Range: 125-175 gm
Number : 20 males
2. Species: Rabbit
Strain: New Zealand White
Supplier Summit View Farm Belvidere, N J
Reason for Species,Choice: Good model for studies involving lymphocyte c u l t u r e
Age on Test: Not defined
Weight range: approximately 2.0 Kg
Number 14 males
Husbandry:
Lights : 12 hours on, 12 hours off
During Exposure Period:
Housing :
Food :
Water :
During Exposure Period:
Housing :Individual in wire mesh cages
Food : none
Water: none
During the non-Exposure period
Housing: Individual in suspended stainless steel wlre mesh bottom cages
Food: Purina Rodent Laboratory Chow 5001 ad libitum.
Water: Tap water with automatic watering system - ad libitum
Quarantine period: Minimum 14 days ( inhalation SOP INH-051)
Administration / exposure
- Route of administration:
- inhalation: vapour
- Vehicle:
- none
- Details on exposure:
- The test item is administrated in the breathing air of the animals since there is a potential for human exposure by this route.
the exposure concentrations will be generated by metering known amounts of the undiluted test material into the chamber air intake.
The glass and stainless seel chambers are operated at an air flow rate that provides 99% equilibration time to or less than 10% of the total exposure time. - Duration of treatment / exposure:
- 5 days/week in the first week, 4 days in the second week.
- Frequency of treatment:
- 6 hours/day
- Post exposure period:
- 1 week
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
10 ppm
Basis:
nominal conc.
- Remarks:
- Doses / Concentrations:
30 ppm
Basis:
nominal conc.
- Remarks:
- Doses / Concentrations:
100 ppm
Basis:
nominal conc.
- No. of animals per sex per dose:
- three groups of 4 rats each and 3 rabbits each is exposed to a vapour of CTFE.
- Control animals:
- yes
- Positive control(s):
- A non inhalation positive control group was considered
Examinations
- Tissues and cell types examined:
- not applicable
- Details of tissue and slide preparation:
- not applicable, SCE frequency were monitored before, during and after exposure period after collection of animal's blood.
- Evaluation criteria:
- In case of test item with unknown and perhaps weak or no SCE inducting potential as CTFE the complete set of data from all animals is considered.
The data are plotted on a linear regression analysis. - Statistics:
- Despite the absence of positive statistical findings using Student's t-test, the X^2-analysis was carried out.
It was again clear from these analysis that CTFE did not induce SCRs in peripheral lynphocytes of either rats or rabbits, and so no further statistical tests were performed.
Results and discussion
Test results
- Sex:
- male/female
- Genotoxicity:
- negative
- Toxicity:
- no effects
- Vehicle controls validity:
- not applicable
- Negative controls validity:
- valid
- Positive controls validity:
- valid
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
Peripheral lymphocyte SCE frequencies were monitored before, during and after the exposure period. CTFE failed to induce significant increases in
SCE frequency at any dose level, and there was no suggestion of a dose response.
The test compound was therefore concluded to be negative in this assay. - Executive summary:
Test animals (rats and rabbits) were exposed to CTFE via inhalation for 6 hours a day, 5 days during week one and 4 days during week two; and their peripheral lymphocyte SCE frequencies were monitored before, during and after the exposure period. Exposure to CTFE failed to induce significant increases in SCE frequency at any dose level, and there was no suggestion of a dose response. This test compound is therefore concluded to be negative in this assay.
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