Diisopropyl succinate

Water solubility

Administrative data

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

June 14-17, 2010

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2010

Report date:

2010

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

GLP compliance:

yes

Type of method:

flask method

Test material

Test material information

Constituent 1

Reference substance name:

Diisopropyl succinate

EC Number:

213-110-0

EC Name:

Diisopropyl succinate

Cas Number:

924-88-9

Molecular formula:

C10H18O4

IUPAC Name:

diisopropyl succinate

Details on test material:

- Name of test material (as cited in study report):diisopropylsuccinate
- Physical state: liquid

Results and discussion

Water solubility

Water solubility 1

Water solubility:

3 637 mg/L

Temp.:

10 °C

pH:

4.5 - 4.6

Remarks on result:

other: standard deviation: 146, replicates of three days

Water solubility 2

Water solubility:

3 772 mg/L

Temp.:

20 °C

pH:

4.3 - 4.5

Remarks on result:

other: standard deviation: 116, replicates of three days

Details on results:

The temperature of the water bath was 10.0 °C respectively 20.0 °C.
The pH of the solutions were 4.5 to 4.6 at 10 °C and 4.3 to 4.5 at 20 °C.
The difference between the concentrations of the test substance of day 1 to 3 at 10 °C
and 20 °C was <15 % and the concentrations of the test substance showed no relevant tendency. Therefore the mean of day 1 - 3 was taken as the
solubility of the test substance at both temperatures, according to the guidelines.
As the temperature coefficient of the solubility of the test substance was <3 % per °C, the solubility was not determined at three temperatures, in
agreement with the guideline.

Any other information on results incl. tables

Table1: Water Solubility at 10 °C

Mass concentration of diisopropylsuccinate determined at different times of stirring, two solutions were used.

 

nominal temperature	equilibration time	pH of the solutions		concentration (mg/L)			deviation from the maximum concentration (%)
		1^st	2^nd	1^st	2^nd	mean
10 °C	1 day	4.6	4.6	3848	3751	3800	0.0
	2 days	4.5	4.4	3604	3592	3598	-5.3
	3 days	4.5	4.5	3534	3496	3515	-7.5
			mean (day 1-3)			3637
			SD			146

 

Table2: Water Solubility at 20 °C

Mass concentration of diisopropylsuccinate determined at different times of stirring, two solutions were used.

 

nominal temperature	equilibration time	pH of the solutions		concentration (mg/L)			deviation from the maximum concentration (%)
		1^st	2^nd	1^st	2^nd	mean
20 °C	1 day	4.4	4.5	3749	3955	3852	0.0
	2 days	4.4	4.3	3881	3770	3825	-0.7
	3 days	4.3	4.3	3640	3639	3640	-5.5
			mean (day 1-3)			3772
			SD			116

 

Applicant's summary and conclusion

Conclusions:

Interpretation of results (migrated information): soluble (1000-10000 mg/L)
The water solubility of diisopropylsuccinate was determined to:
Mean: 3637 mg/L, standard deviation: 146, replicates of three days, temperature 10.0 °C.
Mean: 3772 mg/L, standard deviation: 116, replicates of three days, temperature 20.0 °C.
As the temperature coefficient of the solubility of the test substance was <3 % per °C, the solubility was not determined at three temperatures, in
agreement with the guideline.

Executive summary:

The flask method was used.

The water solubility of diisopropylsuccinate was determined to:
Mean: 3637 mg/L, standard deviation: 146, replicates of three days, temperature 10.0 °C.
Mean: 3772 mg/L, standard deviation: 116, replicates of three days, temperature 20.0 °C.

As the temperature coefficient of the solubility of the test substance was <3 % per °C, the solubility was not determined at three temperatures, in agreement with the guideline.