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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to microorganisms

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Administrative data

Link to relevant study record(s)

Description of key information

NOEC (28 d) ≥ 100 mg/L for activated sludge microorganisms (OECD 301C)

Key value for chemical safety assessment

EC10 or NOEC for microorganisms:
100 mg/L

Additional information

The toxicity of 2,2'-[ethane-1,2-diylbis(oxy)]bisethyl diacetate (CAS 111-21-7) to microorganisms was investigated in a biodegradation study according to OECD 301C under GLP conditions (Clarke, 2012). The study was performed with a mixed population of active sewage sludge microorganisms. A toxicity control included in the biodegradation study could not be evaluated due to technical problems. Nevertheless, no inhibition of biodegradation was observed after 28 d. The test concentration from a biodegradation study which indicated that the test substance is readily biodegradable can be used to derive a NOEC for this endpoint as stated in the ECHA Guidance R.7b (ECHA, 2014). Therefore, the test item concentration of 100 mg/L can be used as NOEC value for the toxicity to activates sludge microorganisms. Thus a NOEC (28 d) of ≥ 100 mg/L resulted.