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EC number: 500-082-2 | CAS number: 32492-61-8 1 - 4.5 moles ethoxylated
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
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- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
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- Nanomaterial porosity
- Nanomaterial pour density
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- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
The short-term toxicity to the aquatic environment of BPA 1-4.5EO was investigated using reliable studies on the substance and BPA 2EO. Short-term toxicity studies on BPA 1-4.5EO indicated that fish was the most sensitive species with a 96-hour LC50 of 64 mg/L, obtained from a GLP-compliant short-term toxicity study performed on Oncorhynchus mykiss according to the OECD Testing Guideline 203.
Aquatic toxicity studies on BPA 2EO showed lower EC50 or LC50 than those obtained on BPA 1-4.5EO for the three trophic levels with algae identified as the most sensitive species with an EC50 of 17.1 mg/L based on growth rate. It was concluded that BPA 2EO was more toxic than BPA 1-4.5EO to fish, aquatic invertebrates, and algae.
Considering that the 96-hour LC50 for fish of BPA 1 -4.5EO is above 1 mg/L, the registered substance does not meet the criteria for classification as acute toxic to the aquatic environment in accordance with Regulation (EC) N° 1272/2008.
There is no available data on the chronic toxicity of the registered substance to the aquatic environment. The Chemical Safety Assessment conducted according to Annex I of REACH did not indicate a need to investigate further the effects to the aquatic environment. Therefore no long-term toxicity testing on aquatic species was performed in accordance with Annex IX, Column 2, of REACH.
Considering that the 96-hour LC50 for fish of BPA 1 -4.5EO is comprised between 10 and 100 mg/L and the substance is not ‘rapidly biodegradable’, the registered substance meets the criteria for classification as Aquatic Chronic 3; H412.
The toxicity of BPA 1-4.5EO to STP microorganisms was assessed using data on Grade 6.3EO of the substance. The study gave a 30-minute EC20 of 230 mg/L based on respiration inhibition. It is concluded that the registered substance is not toxic to STP microorganisms. These results do not impact on the classification of BPA 1-4.5EO.
Additional information
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