1,4-diazabicyclooctane

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Data insufficient for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1979

Report date:

1979

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Deviations:

yes

Remarks:

(limited documentation, exposure time, no analytics on exposure concentration)

Principles of method if other than guideline:

BASF-Test. The test demonstrates the toxicity of an atmosphere saturated with vapour of the volatile components of a test substance at the temperature chosen for vapour generation (20 °C). Groups of 6 rats were exposed to the vapour, generated by bubbling 200 L/h air through a substance column of about 5 cm above a fritted glass disc in a glass cylinder for 7 h. The procedure was repeated with a second group of 6 rats. The documentation of mortality and clinical signs was performed over a period of 8 days.

GLP compliance:

no

Test type:

other: IHT: inhalation hazard test

Test material

Test material information

Constituent 1

Reference substance name:

Kaolin

Cas Number:

1332-58-7

IUPAC Name:

Kaolin

Details on test material:

- Name of test substance (as cited in study report): Lupragen C200 (33% Triaethylendiamin and 67% Dipropylenglycol)
- Analytical purity: no data
- Physical state: liquid
- Substance number: 77/477

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Details on test animals or test system and environmental conditions:

not reported

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

air

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: exsiccator and wash bottle
- Source and rate of air: 200 L air per hour
- System of generating particulates/aerosols: For saturation the air was passed through a circa 5 cm high layer of the compound
- Temperature air chamber: room temperature

TEST ATMOSPHERE
- Samples taken from breathing zone: no.

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

7 h

Concentrations:

no data

No. of animals per sex per dose:

6

Control animals:

yes

Details on study design:

no data

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC0

Effect level:

other: no data

Exp. duration:

7 h

Remarks on result:

other: 0/12 animals died.

Mortality:

no mortality

Clinical signs:

other: no abnormalities

Gross pathology:

no abnormalities