Registration Dossier
Registration Dossier
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EC number: 205-999-9 | CAS number: 280-57-9
Toxicity to birds
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
No studies on the long-term toxicity to birds are available for the
substance.
In Annex X, Section 9.6.1, Column 2 of Regulation (EC) No 1907/2006, it
is laid down that any need for testing should be carefully considered
taking into account the large mammalian dataset that is usually
available at this tonnage level. Furthermore, ECHA (2017) states in the
"Guidance on information requirements and chemical safety assessment
Chapter R.7c" (R.7.10.16) that "given that mammalian toxicity is
considered in detail for human health protection, the need for
additional data for birds must be considered very carefully – new tests
are a last resort in the data collection process."
In case of 1,4-Diazabicyclo[2.2.2]octane (CAS 280-57-9) a mammalian
dataset is available.
In addition, based on the low log Kow and the low estimated BCF,
significant bioaccumulation in organisms is not to be expected (see
IUCLID Ch. 5.3.1). In addition, the hazard assessment of the substance
reveals neither a need to classify the substance as hazardous according
to Regulation EC 1272/2008 and its second adaptation 286/2011, nor is it
a PBT or vPvB substance, nor are there any further indications that the
substance may be hazardous to the environment. The potential
transformation products of the substance were also assessed for their
PBT/vPvB status; none of the 24 relevant transformation products were
identified as PBT/vPvB substances (see IUCLID Ch. 5.2.1/5.2.2/5.2.3).
Therefore, and for reasons of animal welfare, long-term or reproductive
toxicity tests on birds do not need to be conducted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
