Registration Dossier
Registration Dossier
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EC number: 205-999-9 | CAS number: 280-57-9
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The substance is with high probability acutely not harmful to fish.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Dose descriptor:
- LC50
- Effect concentration:
- > 100 mg/L
Additional information
The acute toxicity to fish of 1,4-Diazabicyclo[2.2.2]octane was assessed in a GLP guideline study according to OECD 203 with Cyprinus carpio as test organism (Air Products, 2000, Rep. no. 269303). Analysis of the test concentration showed that the measured concentration was in agreement with nominal concentration. The LC50 of 1,4-Diazabicyclo[2.2.2]octane was found to be > 100 mg/l (without pH adjustment).
In a supporting study with Leuciscus idus (Golden Orfe) according to DIN 38412, Part 15 the LC50 of 1,4-Diazabicyclo[2.2.2]0ctane was found to be >464 mg/L (without pH adjustment). The geometric mean LC50was 681 mg/L. After pH adjustement the LC50 was found to be >1000 mg/L (BASF AG, 1989, Rep. no. 10F0028/895096). The supporting study was performed without analytical monitoring, however, from the available toxicity studies on fish, aquatic invertebrates and algae, conducted with analytical monitoring (Air Products, 2000, Rep. no. 269303 (fish), Rep. no. 269314 (daphnia) and Rep. no. 269325 (algae)), it can be concluded that 1,4-Diazabicyclo[2.2.2]octane is rather stable in static test systems for at least 96 hours. Moreover, the stability of the test substance in the test medium is considered to be stable due to the high water solubility of 610 g/L (see IUCLID Ch. 4.8), the low vapour pressure of 0.42 hPa at 23°C (BASF AG, 2002, Rep. no. 2002.164) and the low Henry´s law constant of 4.74E-004 Pa-m3/mole (HENRYWIN v3.20, EPISuite v4.11, BASF SE, 2022).
Based on these results, the substance is with high probability acutely not harmful to fish.
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