1-nitroguanidine

Water solubility

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

1990

Reliability:

3 (not reliable)

Rationale for reliability incl. deficiencies:

documentation insufficient for assessment

Qualifier:

equivalent or similar to guideline

Guideline:

other: not reported

Principles of method if other than guideline:

The aqueous solubility was determined by suspending 0.1 g of nitroguanidine in each of three centrifuge tubes containing 25 ml of water; the tubes were rotated for 4 d in a closed chamber at 25 °C and then centrifuged at 10000 rpm for 60 min; the nitroguanidine was analyzed directly in the aqueous fraction by HPLC.

GLP compliance:

not specified

Type of method:

other: not mentioned in detail

Specific details on test material used for the study:

Test substance supplier: Aldrich Chemical Co
Water content 25%

Key result

Water solubility:

2.6 g/L

Conc. based on:

test mat. (total fraction)

Temp.:

25 °C

Remarks on result:

other: pH value was not specified

Six experiments were conducted at 25 °C.

Conclusions:

Nitorguanidine is soluble (1000-10000 mg/l) in water.

Executive summary:

The water solubility of nitroguanidine was determined by suspending 0.1 g of nitroguanidine in each of three centrifuge tubes containing 25 ml of water; the tubes were rotated for 4 d in a closed chamber at 25 °C and then centrifuged at 10000 rpm for 60 min; the nitroguanidine was analyzed directly in the aqueous fraction by HPLC. Six experiments were conducted at 25 °C. The water solubility was measured to be 2.6 +-0.1 g/l at 25 °C.

Reference 2

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

September 1982 - October 1982

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

secondary literature

Remarks:

This is a review of environmental fate, although comprehensive and useful for extracting physico-chemical data and general fate information.

Qualifier:

equivalent or similar to guideline

Guideline:

other: not reported

Principles of method if other than guideline:

Information on physico-chemical properties was taken from "Encyclopedia of Explosives and Related Items. PATR2700 Vol. 6. Picatinny Arsenal, Dover, NJ (1974)"

GLP compliance:

not specified

Type of method:

other: not mentioned, secondary literature

Specific details on test material used for the study:

Test substance supplied by Sunflower AAP

Key result

Water solubility:

4.4 g/L

Conc. based on:

test mat. (total fraction)

Temp.:

25 °C

Remarks on result:

other: pH value was not specified

Water solubility:

83.5 g/L

Conc. based on:

test mat. (total fraction)

Temp.:

100 °C

Remarks on result:

other: pH value was not specified

The information was taken from "Encyclopedia of Explosives and Related Items. PATR2700 Vol. 6. Picatinny Arsenal, Dover, NJ (1974)".

Conclusions:

Nitorguanidine is soluble (1000-10000 mg/l) in water.

Executive summary:

The study is a data base assessment of environmental fate aspects of nitroguanidine including information to water solubility. The information was taken from "Encyclopedia of Explosives and Related Items. PATR2700 Vol. 6. Picatinny Arsenal, Dover, NJ (1974)". The water solubility is 4.4 g/l at 25 °C and 83.5 g/l at 100 °C.

Reference 3

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

secondary literature

Qualifier:

equivalent or similar to guideline

Guideline:

other: not reported

Principles of method if other than guideline:

Secondary literature, details on methods not reported.

GLP compliance:

not specified

Type of method:

other: not mentioned: secondary literature

Specific details on test material used for the study:

Test substance supplier not specified.

Key result

Water solubility:

3.4 g/L

Conc. based on:

test mat. (total fraction)

Temp.:

25 °C

Remarks on result:

other: pH not specified

The following values from different sources are stated: 2.6 (+-0.1) g/l at 25 °C, 4.2 g/l at 25 °C, 4.4 g/l at 25 °C, and 90.0 g/l at 100 °C.

Conclusions:

Nitorguanidine is soluble (1000-10000 mg/l) in water.

Executive summary:

The information is extracted from secondary literature published by the Environmental Agency R&D Dissemination Centre. The following values from different sources are stated: 2.6 (+-0.1) g/l at 25 °C, 4.2 g/l at 25 °C, 4.4 g/l at 25 °C, and 90.0 g/l at 100 °C. An average aqueous solubility of 3.4 g/l at 25 °C is recommended for use.

Description of key information

There are four different literature sources available for the weight of evidence.

All results indicate that nitroguanidine is soluble in water (1000-10000 mg/l).

Key value for chemical safety assessment

Water solubility:

3 g/L

at the temperature of:

20 °C

Additional information

The study of AlzChem is chosen for robust study summary because of the reference temperature of 20 °C instead of 25 °C as well as the fact as the information source is the data owner (information source material safety data sheet).

According to four different literature sources nitroguanidine is soluble (1000-10000 mg/l) in water:

-         3.0 g/l at 20 °C (according to AlzChem, 2008)

-         2.6, 3.4, and 4.4 g/l at 25 °C (according to Haag et al., 1990, Environment Agency R&D Dissemination Centre, and       Kenyon, 1982, respectively)

-         83.5 g/l at 100 °C (according to Kenyon, 1982)