Registration Dossier
Registration Dossier
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EC number: 223-055-4 | CAS number: 3710-84-7
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Pre-guideline study with limited details
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
- Principles of method if other than guideline:
- Pre-guideline study
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- N,N-diethylhydroxylamine
- EC Number:
- 223-055-4
- EC Name:
- N,N-diethylhydroxylamine
- Cas Number:
- 3710-84-7
- Molecular formula:
- C4H11NO
- IUPAC Name:
- N,N-diethylhydroxylamine
- Details on test material:
- - Name of test material (as cited in study report): Anhydrous diethylhydroxylamine #2697
- Analytical purity: no data
- Lot/batch No.: no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: albino
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- Four albino rabbits were used at each of four dosage levels. Individual doses were applied to the fur-clipped skin of the trunk under a pre-fitted occluding sleeve on each animal. The sleeves were renoved 24 hours later and surviving animals were observed for seven days.
- Doses:
- 707, 1000, 1414, 2000 mg/kg
- No. of animals per sex per dose:
- 4
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 1 300 mg/kg bw
- 95% CL:
- 995 - 1 690
- Mortality:
- Skin dose(mg/kg) No.rabbits(dead/total) Time for deaths (hours)
707 0/4 - - - -
1000 1/4 - - - >26
1414 2/4 - - <20, >26
2000 4/4 <20, <20, <20, >26 - Clinical signs:
- other: Hypersensitivity, mydriasis, and incoordination prior to toxic incapacitation.
- Gross pathology:
- No data
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Executive summary:
In a pre-guideline study, groups of 4 albino rabbits were treated dermally under a pre-fitted occluding sleeve with 707, 1000, 1414 and 2000 mg/kg body weight of diethylhydroxylamine. The occluding sleeve was removed 24 hours following exposure and the animals were observed for 7 days. No rabbit died at 707 mg/kg/bw, at 1000 mg/kg bw, 1/4 rabbit died, at 1414 mg/kg bw, 2/4 rabbits died and at 2000 mg/kg bw, all rabbits died. The clinical signs observed were hypersensitivity, mydriasis, and incoordination prior to toxic incapacitation. The acute dermal LD50was 1300 mg/kg bw.
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