Registration Dossier
Registration Dossier
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EC number: 203-921-8 | CAS number: 111-92-2
Carcinogenicity
Administrative data
Description of key information
No valid data available concerning carcinogenic effects.
Under certain conditions the substance can form nitrosamines. Nitrosamines are carcinogenic in animal studies.
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
No valid data available concerning carcinogenic effects.
Additional information
Ultrastructural changes in liver tissue of mice fed nitrosamine precursors, 1000 ppm of the test substance and 2000 ppm nitrite, were observed. 6 months of chronic treatment with the combination resulted in swelling of mitochondria and distension of smooth ER, and after 12 months, an increased incidence of nodules, necrotic foci and hepatoma was found. Degenerative or neoplastic liver changes were not found in controls or in animals of treatment groups receiving a diet supplemented with soybean or ascorbic acid. The effect of the test substance, in the absence of exogenous nitrite, was not investigated.
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