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EC number: 202-715-5 | CAS number: 98-94-2
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
DMCHA is considered as acutely harmful to aquatic organisms, however observed effects on mortality at higher test concentrations may be related to elevated pH values.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Dose descriptor:
- LC50
- Effect concentration:
- 28 mg/L
Additional information
The short-term toxicity to fish was examined in a GLP-study based on OECD guideline 203 with Oncorhynchus mykiss as test organism (Mayes et al, 1989). Chemical analysis of test item concentrations resulted in recovery rate of 64 - 137.5% of nominal concentrations with standard deviations of 11 - 60 %. The 96 hour LC50 value was calculated to be 28.1 mg/L (95% CI: 22.0 to 34.9 mg/L). Observations after 3 h of exposure showed, that there was 100% mortality at 43.9 mg/L and above; the pH at these concentrations exceeded 9.0 and may have contributed to mortality. Optimal pH range according to OECD guideline 203 is 6 - 8.5.
Results of a non-GLP study, conducted with Leuciscus idus and according to the German Standard Test Guideline, DIN 38 412 L15, 1982 (which is comparable to OECD 203) support these findings (BASF AG, 1988). No analytical verification was performed, therefore results of the study were based on nominal exposure concentrations. However it is assumed that the test concentrations remained stable over the exposure period based on results of the study by Mayes et al. (1989) and a sufficient water solubility, a low vapour pressure (3.17 hPa at 25 °C, BASF AG, 1970, BASFAG170.394.1) a low Henry's Law constant (3.01 Pa*m³/mol, VP/WS method, BASF SE, 2015) and a low adsorption potential (log Kow = 2.01, BASF AG, 1988, Rep. no. 122968/01). The 96h LC50 was observed to be > 21.5 mg/L and <46.5 mg/L, the corresponding NOEC was 21.5 mg/L. After pH adjustment of the highest test concentration (100 mg/L) the 96h LC50 was >100 mg/L and the corresponding NOEC was 100 mg/L.
Based on these results, DMCHA is considered to be harmful to aquatic organisms. However, observed effects on mortality at higher test item concentrations may be related to high pH values, which exceeded 9.0. These effects on mortality were not observed, after pH-adjustment.
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