Registration Dossier
Registration Dossier
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EC number: 233-131-9 | CAS number: 10042-76-9
Immunotoxicity
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
Read across from SrCl2 to Sr(NO3)2is envisaged due to the fact that possible effects occurred could be regarded as strontium ion related effects. Both substances (SrCl2 and Sr(NO3)2) are "very soluble" (above 10 g/L at 20°C) in water. Hence, it could be concluded that read across is possible.
In vitro experiments demonstrated that strontium is able to stimulate the release of histamine from mast cells but with a lower efficiency than calcium (Foreman and Mongar, 1972; Foreman, 1977). In addition, strontium stimulated the secretion of 5-hydroxytryptamine in washed human platelets (Best et al., 1981). It was concluded that strontium activates the liberation of arachidonate from membrane phospholipids, with the subsequent biosynthesis of thromboxane A2. The addition of strontium chloride to diluted rabbit serum in vitro inhibited the bactericidal actions of the serum (Toshioka et al., 1974). This effect was attributed to the inhibition of the complement.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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