Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-328-4 | CAS number: 105-76-0
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Rainbow trout LC50 (96 hrs): 1.2 mg/l (static, nominal). 0.6 mg/L (static, geometric mean of the test substance concentration)
Leuciscus idus LC50 (48 hrs): 6 mg/l (static, nominal)
Leuciscus idus LC0 (48 hrs): 5 mg/l, 12 mg/l (both static and nominal)
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 0.6 mg/L
Additional information
Three studies are available for dibutyl maleate, reporting effects of the substance to fish. One study was conducted according to OECD 203, using Rainbow trout as test organism and including analytical measurement of the test substance concentration. In this study, a LC50 of 1.2 mg/l dibutyl maleate was reported. A NOEC could not be determined due to the fact that mortality also occurred in the lowest test concentration. As the test concentration decreased during the test, it was readjusted to 100% after 48 hours of exposure. Therefore, the results are related to the geometric mean of the test concentrations.
Two supporting studies were conducted using the German national standard DIN 38412 both using Golden orfe as test organism. In both tests, the exposure period was 48 hours. The first test reported a LC50 of 6 mg/l, the second one a LC0 of 12 mg/l. The values were also referred to nominal values, however, no analytical measurement conducted. As the study using Rainbow trout as test organism resulted in the lowest LC50 values of all of these studies, including analytical measurement, it was selected as the key study.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
