Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-279-1 | CAS number: 118-82-1
Long-term toxicity to fish
Administrative data
- Endpoint:
- adult fish: sub(lethal) effects
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Accepted QSAR model
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- other: ECSAR model prediction
- Title:
- EPISIUTE model predictions for 4,4'-methylene bis(2,6-di-tertbutyl phenol)
- Author:
- Jacobi S
- Year:
- 2 013
- Bibliographic source:
- US Environmental Protection Agency Office of Pollution Prevention and Toxics and Syracuse Research Corporation. EPI Suite TM 2000-2012
- Report date:
- 2013
Materials and methods
- Principles of method if other than guideline:
- QSAR using ECOSAR v 1.11, US, EPA
Trainig data set: polyphenols and baseline toxicity Neutral organic SAR
Test material
- Reference substance name:
- 2,2',6,6'-tetra-tert-butyl-4,4'-methylenediphenol
- EC Number:
- 204-279-1
- EC Name:
- 2,2',6,6'-tetra-tert-butyl-4,4'-methylenediphenol
- Cas Number:
- 118-82-1
- Molecular formula:
- C29H44O2
- IUPAC Name:
- 2,6-di-tert-butyl-4-[(3,5-di-tert-butyl-4-hydroxyphenyl)methyl]phenol
Constituent 1
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 14 d
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 0.003 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- other: chronic toxicity estimate QSAR plyphenols duration minimum 14 d
- Remarks on result:
- other: concentration above the solubility limit as predicted by the model
- Duration:
- 14 d
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 0.038 µg/L
- Nominal / measured:
- estimated
- Conc. based on:
- test mat.
- Basis for effect:
- other: chronic toxicity estimate QSAR neutral organics duration minimum 14 d
- Remarks on result:
- other: concentration above the solubility limit as indicated by the model
- Details on results:
- Based on Acute to chronic toxixicty ratios of classes of substances. Applicability domain log Kow 8. log Kow used: 8.993. The prediction is on the limit of the applicability domain of the model.
Applicant's summary and conclusion
- Conclusions:
- The model predicts a toxicity level above the solubility limit. This is consistent with the existing experimental data.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
