Registration Dossier
Registration Dossier
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EC number: 203-091-7 | CAS number: 103-24-2
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
No toxic effects up to the limit of water solubility (< 0.0004 mg/L in aqua dest) for Cyprinus carpio (OECD 203)
Key value for chemical safety assessment
Additional information
Two studies investigating the short-term toxicity of Bis(2 -ethylhexyl) azelate (CAS 103-24-2) to freshwater fish are available. The static key study was conducted according to GLP and OECD guideline 203 using Cyprinus carpio as test organism (Bogers, 1998). Siphoned test solutions in concentrations of 1 to 1000 mg/L were applied. The appearance of the final test solutions ranged from clear and colourless to turbid at the higher test concentrations. A 96 h-LC50 value of > 1000 mg/L is determined on the basis of the nominal concentration. As observed undissolved test material was not removed from the treatments, adverse effects could either be caused by systemic toxicity or by physical interferences. However, as no mortality was observed in any treatment the test can be considered as appropriate to assess the hazard of the substance to fish.
A supporting study confirms the results of the key study. The study was conducted by a Japanese authority according to GLP and OECD guideline 203 using Oryzias latipes as test organism (MOE, 2004). A technical product of the substance (77.2% purity) was tested at a nominal test concentration of 0.1 mg/L using HCO-40 as vehicle. A measured test concentration of 0.0723 mg/L can be considered as highest achievable test substance concentration using a vehicle under test conditions. No mortality was observed during an exposure time of 96 h. Hence, the 96 h-LC50 is determined to be > 0.0723 mg/L (meas.) and thus above the solubility of the substance in water.
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