Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Genetic toxicity in vitro

Description of key information

Valeryl chloride did not cause gene mutations in Salmonella typhimurium and Escherichia coli (Ames test).

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (negative)

Genetic toxicity in vivo

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Valeryl chloride was tested in the Ames reverse mutation assay (GLP compliant OECD guideline 471/472 study) using Salmonella typhimurium strains TA98, TA100, TA1535 and TA1537 and Escherichia coli WP2 uvr A at 20 to 5000 µg/plate (standard plate test) and 20 to 1500 µg/plate (preincubation test) with and without metabolic activation (1997). No precipitation of the test substance was found. A bacteriotoxic effect was observed at doses from 1,500 µg/plate (standard plate test) or from 500 µg/plate (preincubation test). Under the conditions tested, an increase in the number of his+ or trp+ revertants was not observed both in the standard plate test and in the preincubation test either without S-9 mix or after the addition of a metabolising system.

Justification for classification or non-classification

Based on the results of the Ames test, valeryl chloride does not need to be classified according to the EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.