Registration Dossier
Registration Dossier
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EC number: 202-297-4 | CAS number: 94-04-2
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
Effects on developmental toxicity
Description of key information
Vinyl 2-ethylhexanoate showed developmental toxicity in rats at 750 mg/kg/day with an NOAEL of 350 mg/kg/day. In a developmental toxicity study in rabbits a maternal toxicity was observed in one rabbit at 350 mg/kg/day with a NOAEL at 100 mg/kg/day
Effect on developmental toxicity: via oral route
- Dose descriptor:
- NOAEL
- 350 mg/kg bw/day
Additional information
Vinyl 2 -ethylhexanoate is a developmental toxicant in rats in the absence of maternal toxicity causing a slight increase in the external malformation filamentous tail together with various skeletal variants, reduced ossification and reduced foetal body weight indicative of developmental retardation. The NOEL for maternal toxicity was 750 mg/kg/day and the NOEL for developmental toxicity was 350 mg/kg/day.
In rabbits vinyl 2 -ethylhexanoate did not cause developmental effects in the absence of maternal toxicity. The 750 mg/kg/day level exceeded the maximum tolerated dose and this precluded a definitive assessment of developmental toxicity at this dose level. TheNOEL for maternal toxicity was 100 mg/kg/day and the NOAEL for developmental toxicity was 350 mg/kg/day.
Justification for classification or non-classification
Additional information
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