Registration Dossier
Registration Dossier
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EC number: 202-297-4 | CAS number: 94-04-2
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Not a GLP or O.E.C.D. Testing Guideline study with few details on experimental dosing and results.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- no
Test material
- Reference substance name:
- Vinyl 2-ethylhexanoate
- EC Number:
- 202-297-4
- EC Name:
- Vinyl 2-ethylhexanoate
- Cas Number:
- 94-04-2
- Molecular formula:
- C10H18O2
- IUPAC Name:
- ethenyl 2-ethylhexanoate
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Male and female rabbits were dosed with 0.5 ml of test material under an occluded patch for 4 hours on intact skin. Excess sample is removed and the rabbits are observed for 14 days. Irritation is scored by the Draize method.
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: intact
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5 ml undilute
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 14 days
- Number of animals:
- 3 male and 3 female
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Remarks:
- mean score
- Time point:
- other: 5 hours
- Score:
- 2.9
- Reversibility:
- fully reversible within: 7 days
- Irritant / corrosive response data:
- A 4 hour application of 0.5 ml o vinyl 2-ethylhexanoate to occluded rabbit skin resulted in minor to moderate erythema and edema on 6 of 6 rabbits. By 3 days only minor irritation persisted on 2 rabbits. The skin of all 6 rabbits had a normal appearance after 7 days.
Applicant's summary and conclusion
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information
- Conclusions:
- Minor to moderate erythema and edema on 6 of 6 rabbits, which subsided completely after 7 days.
- Executive summary:
An Acute Dermal Irritation/Corrosion study was conducted with undiluted Vinyl 2 -ethylhexanoate in six rabbits. The exposure conditions were 6 -hr under occlusion. Based on results from this test, vinyl 2 -ethylhexanoate can be classified as a Catagory 3 mild irritant to rabbit skin under conditions of the test. The results from this study are appropriate and reliable for predicting the skin irritation potential of Vinyl 2 -ethylhexanoate
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