Registration Dossier
Registration Dossier
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EC number: 601-722-4 | CAS number: 120570-77-6
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
EC50 (72 h): 207.8 mg/L for Skeletonema costatum (ISO 10253)
EC10 (72 h): 90.6 mg/L for Skeletonema costatum (ISO 10253)
Key value for chemical safety assessment
- EC50 for marine water algae:
- 207.8 mg/L
- EC10 or NOEC for marine water algae:
- 90.6 mg/L
Additional information
One experimental study investigating the toxicity of diethyleneglycol diformate (CAS 120570-77-6) to marine algae is available (Rowlands, 2008). The study was performed according to ISO 10253:2006(E) under GLP conditions using the marine algae Skeletonema costatum. Test substance concentrations from 100 - 1000 mg/L (nominal) were tested in the study. After an exposure of 72 h an EC50 of 207.8 mg/L and an EC10 of 90.6 mg/L were calculated based on growth rate.Since the substance is susceptible to abiotic hydrolysis (DT50: 1.24 d (pH7) and 2.98 h (pH8) (HYDROWIN v2.00)) the result reflects the effectsof the parent substance as well as the hydrolysis products.It was observed that the pH at the start of the study was slightly below the acceptable tolerance limit at test concentrations of 316.2, 562.3 and 1000.0 mg/L. This appeared to be due to the nature of the test material. It is reported that this minor deviation did not affect the result and therefore the reliability of the study. The pH of the control and reference substance were fractionally above the acceptable tolerance limits. Furthermore, the pH of the control did not increase by more than 1 unit during the test (validity criterion, pH ranged from 8.21 (test start) to 8.55 (test end)).
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