Registration Dossier

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

Evidence from two studies in guinea pigs indicates that diethyltoluenediamine does not possess skin sensitization potential (Gabriel 1977; Nelson et al. 1977).

Migrated from Short description of key information:
Two sensitization studies with guinea pigs demonstrated that the test material is not a sensitizing agent (Gabriel 1977; Nelson et al. 1977).

Justification for classification or non-classification

The negative findings reported by Gabriel (1977) and Nelson et al. (1977) support that the test substance is not a skin sensitizing agent. Therefore, the GHS criteria for classification are not applicable to this substance. See: Regulation (EC) No 1272/2008; See Official Journal of the European Union, (2008) Vol. L353, pp. 1-1355, at p. 97.